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1.
Pharmazie ; 59(11): 819-23, 2004 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-15587578

RESUMO

An HPLC qualitative and quantitative method of seven analytes (caffeine, ephedrine, forskolin, icariin, pseudoephedrine, synephrine, and yohimbine) in thermogenic weight loss preparations available on the market is described in this paper. After 45 min the seven analytes were separated and detected in the acetonitrile: water (80:20) extract. The method uses a Waters XTerra RP18 (5 microm particle size) column as the stationary phase, a gradient mobile phase of water (5.0 mM SDS) and acetonitrile, and a UV detection of 210 nm. The correlation coefficients for the calibration curves and the recovery rates ranged from 0.994 to 0.999 and from 97.45% to 101.05%, respectively. The qualitative and quantitative results are discussed.


Assuntos
Fármacos Antiobesidade/análise , Regulação da Temperatura Corporal/efeitos dos fármacos , Calibragem , Cromatografia Líquida de Alta Pressão , Medicamentos sem Prescrição/análise , Plantas Medicinais/química , Pós , Padrões de Referência , Espectrofotometria Ultravioleta , Comprimidos
2.
J Ethnopharmacol ; 94(2-3): 245-9, 2004 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-15325726

RESUMO

Aristolochia species have been administered by those trained in traditional Chinese medicine (TCM) for centuries. After determining Aristolochia fangchi was an adulterant that caused death due to renal failure in a number of patients at a Belgian weight loss clinic, many countries took steps to regulate products containing Aristolochia fangchi as well as other Aristolochia species. The US FDA issued a Consumer Advisory 'advising consumers to stop using any products that may likely contain aristolochic acid'. The Aristolochia and Asarum genera both have been found to contain aristolochic acids. A number of websites have been found from which individuals can order products containing either Aristolochia or Asarum as an ingredient through US merchants. We purchased 25 products from such sites and analyzed them for the presence of aristolochic acid I and II by HPLC with PDA. Six of the products contained detectable amounts of I and II.


Assuntos
Aristolochia , Asarum , Medicamentos de Ervas Chinesas/análise , Animais , Medicamentos de Ervas Chinesas/química , Humanos
3.
Pharmazie ; 58(6): 381-4, 2003 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12856998

RESUMO

An improved HPLC qualitative and quantitative method of six triterpenes (asiaticoside, madecassoside, asiatic acid, madecassic acid, terminolic acid, and asiaticoside-B) in Centella asiatica (raw plant material and preparations) is described in this paper. After 50 minutes the six active triterpenes were separated and detected in the methanolic extract at a limit of 0.01 microg/ml. The method uses a Phenomenex Aqua 5mu C18 (200 A) column as the stationary phase, a gradient mobile phase of water (0.1% TFA), acetonitrile (0.1% TFA), and methyl tert-butyl ether (0.1% TFA), and UV detection at 206 nm. The correlation coefficients for the calibration curves and the recovery rates ranged from 0.995 to 0.999 and from 98.39% to 100.02%, respectively. The qualitative and quantitative results are discussed.


Assuntos
Centella/química , Triterpenos/análise , Calibragem , Cápsulas , Cromatografia Líquida de Alta Pressão , Suplementos Nutricionais/análise , Extratos Vegetais/análise , Padrões de Referência , Soluções
4.
Pharmazie ; 57(10): 686-9, 2002 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-12426949

RESUMO

Wild ginger, Asarum canadense, which has folk uses as a medicinal and food plant, has been reported to contain aristolochic acid I. Rhizomes of North American species of Aristolochiaceae were surveyed for the presence of aristolochic acids by HPLC. Aristolochic acid I (1) and aristolochic acid II (2) were present in Aristolochia species and Hexastylis; 1 alone was detected in multiple accessions of A. canadense and Asarum caudatum, though not in Asarum wagneri. Concentrations in A. canadense were highly variable, reaching as much as 0.037 percent of dry weight.


Assuntos
Aristolochia/química , Ácidos Aristolóquicos/análise , Asarum/química , Calibragem , Cromatografia Líquida de Alta Pressão , América do Norte , Padrões de Referência
5.
J Nat Prod ; 64(5): 624-6, 2001 May.
Artigo em Inglês | MEDLINE | ID: mdl-11374957

RESUMO

Two new dihydroagarofuran sesquiterpene alkaloids, putterines A (2) and B (3), and a known alkaloid, mayteine (1), were isolated from the root of Maytenus putterlickoides. The structures of these compounds were elucidated by various spectroscopic techniques, including 1H and 13C NMR, COSY, ROESY, HMBC, and high-resolution FABMS.


Assuntos
Alcaloides/química , Plantas Medicinais/química , Sesquiterpenos/química , Alcaloides/isolamento & purificação , Espectroscopia de Ressonância Magnética , Sesquiterpenos/isolamento & purificação , Espectrometria de Massas de Bombardeamento Rápido de Átomos , Espectrofotometria Infravermelho , Espectrofotometria Ultravioleta
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